Environmental Effects On Drosophila Brain Development And Learning

Brain development and behavior are sensitive to a variety of environmental influences including social interactions and physicochemical stressors. Sensory input in situ is a mosaic of both enrichment and stress, yet little is known about how multiple environmental factors interact to affect brain anatomical structures, circuits and cognitive function. In this study, we addressed these issues by testing the individual and combined effects of sub-adult thermal stress, larval density and early-adult living spatial enrichment on brain anatomy and olfactory associative learning in adult Drosophila melanogaster. In response to heat stress, the mushroom bodies (MBs) were the most volumetrically impaired among all of the brain structures, an effect highly correlated with reduced odor learning performance. However, MBs were not sensitive to either larval culture density or early-adult living conditions. Extreme larval crowding reduced the volume of the antennal lobes, optic lobes and central complex. Neither larval crowding nor early-adult spatial enrichment affected olfactory learning. These results illustrate that various brain structures react differently to environmental inputs, and that MB development and learning are highly sensitive to certain stressors (pre-adult hyperthermia) and resistant to others (larval crowding). © 2018. Published by The Company of Biologists Ltd

Non-genetic Transgenerational Inheritance of Acquired Traits in Drosophila

It is increasingly recognized that acquired traits may be transgenerationally transmitted through non-DNA sequence-based elements, with epigenetics as perhaps the most important mechanism. Here we review examples of non-genetic transgenerational inheritance in Drosophila, highlighting transgenerational programming of metabolic status and longevity, one particular histone modification as an evolutionarily conserved underlying mechanism, and important implications of such studies in understanding health and diseases

Quenched lattice calculation of semileptonic heavy-light meson form factors

We calculate, in the continuum limit of quenched lattice QCD, the matrix elements of the heavy-heavy vector current between heavy-light pseudoscalar meson states. We present the form factors for different values of the initial and final meson masses at finite momentum transfer. In particular, we calculate the non-perturbative correction to the differential decay rate of the process B --> D l nu including the case of a non-vanishing lepton mass.Comment: 16 pages, 10 figures, version accepted for publication on JHE

Corporate governance and intellectual capital disclosure : evidence from the Scandinavian countries

In the modern society intellectual capital (IC) disclosure offers valuable insights on the information transparency between the organisation and its stakeholders. The purpose of the present study is to analyse the determinants of IC disclosure based on the firm data collected from the Scandinavian countries. We have chosen to analyse 123 annual reports in the local language for the period of 2008 to 2012. The annual reports act as one of the best sources of data revealing important information about firms that are beyond the reporting requirements of the accounting regulations. This paper combines the empirical research of IC disclosure with the previous literature to identify its strategic implications on corporate governance. The aim is to examine the relationship between firm size, leverage ratio, information asymmetry and industry-specific factors on the level of IC disclosure. Our results call the potential need for more IC disclosure

Impact des résultats passés sur l’aversion au risque de l’investisseur (The impact of past results on the investor's risk).

Dans un contexte de crise, il est facile de perdre ses repères, et les comportements irrationnels actuels, la panique généralisée des investisseurs le démontrent. Alors que de nombreuses cessations de paiement des ménages américains étaient constatées depuis plusieurs mois, de nombreux investisseurs ont continué à acheter des produits liés au marché des subprimes. Une lecture de l’histoire financière souligne le caractère récurrent et global des anomalies de marché. Le présent article cherche à savoir en quoi de bons résultats financiers passés influencent l’aversion au risque d’un investisseur. In a context of crisis, it is easy to lose its points of reference; the current irrational behaviours and the general panic of investors demonstrate it. While for sevenal months, many american households have been unable to meet their financial obligation, some investors have kept on buying financial products linked to the market of the subprimes. An interpretation of the financial history underlines the recurring and global character of the markets' abnormalities. The present article tries to know how good financial results achieved in the past can influence the investor’s risk aversion.irrational behaviors, financial history, investor’s risk aversion

Microstructural contributions of different polyolefins to the deformation mechanisms of their binary blends

The mixing of polymers, even structurally similar polyolefins, inevitably leads to blend systems with a phase-separated morphology. Fundamentally understanding the changes in mechanical properties and occurring deformation mechanisms of these immiscible polymer blends, is important with respect to potential mechanical recycling. This work focuses on the behavior of binary blends of linear low-density polyethylene (LLDPE), low-density polyethylene (LDPE), high-density polyethylene (HDPE), and polypropylene (PP) under tensile deformation and their related changes in crystallinity and morphology. All of these polymers plastically deform by shear yielding. When unmixed, the high crystalline polyolefins HDPE and PP both exhibit a progressive necking phenomenon. LDPE initiates a local neck before material failure, while LLDPE is characterized by a uniform deformation as well as clear strain hardening. LLDPE/LDPE and LLDPE/PP combinations both exhibit a clear-cut matrix switchover. Polymer blends LLDPE/LDPE, LDPE/HDPE, and LDPE/PP show transition forms with features of composing materials. Combining PP in an HDPE matrix causes a radical switch to brittle behavior

Marla Sokolowski: and now for someone completely different

A comprehensive science, technology, engineering, and mathematics (STEM) education has persistent formative effects on individuals, communities, and society. In this regard, Marla Sokolowski’s academic legacy will forever reflect her unique contributions to STEM education and mentoring. Furthermore, her creative and multidisciplinary approach to research has resulted in groundbreaking advances in our understanding of behavior genetics. Illustrated here are a few of our life-long learning experiences drawn mainly from earlier parts of Marla’s careerinfo:eu-repo/semantics/publishedVersio

The response of neotropical dragonflies (Insecta: Odonata) to local and regional abiotic factors in small streams of the Amazon

Since the relative role of local and regional abiotic factors on the Odonata diversity in rainforest streams is still poorly understood, we evaluated the effects of these factors on adult Odonata (Insecta) from preserved and altered streams in the Amazonian region. Adult Odonata were sampled in 98 streams in the Eastern Amazon, Pará, Brazil. Six variables were used to measure local environmental factors: habitat integrity index; mean canopy over the channel; and four physical and chemical descriptors of the water. To measure regional environmental factors, six variables were also used: altitude gradient, three bioclimatic variables and two percentage forest variables. In partial redundancy analysis, both abiotic factors (local and regional) were important to explain the variation in the Odonata community. The Odonata community can be influenced by regional and local factors. The relationship between Odonata and the local (e.g., integrity, canopy cover, and physical and chemical descriptors of the water) and regional (e.g., bioclimatic and forest cover variables) environmental variables recorded in this study has important implications for the use of these organisms to monitor small streams of the Eastern Amazon. The scale at which habitat is measured is an important issue in community structuring studies considering the rapid environmental changes. It is of great importance to consider the different scales in studies assessing community structure, once an adequate habitat must meet the ecological needs of all stages of the life of the Odonata.Funding Agency National Council for Scientific and Technological Development (CNPq) CNPq Amazonian Biodiversity and Land Use project CNPq 574008/2008-0 Brazilian Agricultural Research Company-EMBRAPA SEG: 02.08.06.005.00 Darwin Initiative, United Kingdom 17-023 Nature Conservancy and Natural Environment Research Council (NERC) NE/F01614X/1 NE/G000816/1 National Council for Scientific and Technological Development (CNPq) 307597/2016-4 Portuguese Foundation for Science and Technology UID/Multi/04326/2019 PROPESP/UFPA through Edital 01/2018 (Programa de Apoio a Publicacao Qualificada-PAPQ)info:eu-repo/semantics/publishedVersio

Metamorphosis of the Mushroom Bodies; Large-Scale Rearrangements of the Neural Substrates for Associative Learning and Memory in Drosophila

Paired brain centers known as mushroom bodies are key features of the circuitry for insect associative learning, especially when evoked by olfactory cues. Mushroom bodies have an embryonic origin, and unlike most other brain structures they exhibit developmental continuity, being prominent components of both the larval and the adult CNS. Here, we use cell-type-specific markers, provided by the P{GAL4} enhancer trap system, to follow specific subsets of mushroom body intrinsic and extrinsic neurons from the larval to the adult stage. We find marked structural differences between the larval and adult mushroom bodies, arising as the consequence of large-scale reorganization during metamorphosis. Extensive, though incomplete, degradation of the larval structure is followed by establishment of adult specific α and β lobes. Kenyon cells of embryonic origin, by contrast, were found to project selectively to the adult γ lobe. We propose that the γ lobe stores information of relevance to both developmental stages, whereas the α and β lobes have uniquely adult roles